Assisted reproductive technologies and the risk of stillbirth in singleton pregnancies: a systematic review and meta-analysis

ObjectiveTo identify the risk of stillbirth from in vitro types assisted reproductive technologies compared with spontaneous conception (SC), limited to singleton births.DesignSystematic literature search and chaining on online databases: PubMed, Embase, Scopus.SettingNot applicable.Patient(s)Singleton pregnancies fertilization (IVF) or by IVF intracytoplasmic sperm injection (IVF-ICSI).Intervention(s)Not applicable.Main Outcome Measure(s)Adjusted odds ratio for prevalence case–control groups IVF/IVF-ICSI singletons SCs, respectively, matched studies.Result(s)A total 19 studies were included, study quality was mixed. Ten qualified inclusion meta-analysis, which revealed a significantly increased that SC (odds [95% confidence interval]: 1.82 [1.37–2.42]), there no evidence publication bias.Conclusion(s)In IVF-ICSI treatment increases natural conception.Clinical Trial Registration NumberPROSPERO 216768. To births. Systematic Scopus. Not applicable. Singleton (IVF-ICSI). Adjusted studies. A bias. In conception.